CASCADA DE LA COAGULACION VIA INTRINSECA PDF

The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but it is flawed as a model of the in vivo hemostatic process. Hemostasis requires both platelet and fibrin plug formation at the site of vessel injury and that the procoagulant substances activated in this process remain at the site of injury. This control of blood coagulation is accomplished as the procoagulant reactions only exist on specific cell surfaces to keep coagulation from spreading throughout the vascular system. A model of coagulation that better explains bleeding and thrombosis in vivo created after considering the critical role of cells.

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The concept of a coagulation cascade describes the biochemical interactions of the coagulation factors, but it is flawed as a model of the in vivo hemostatic process. Hemostasis requires both platelet and fibrin plug formation at the site of vessel injury and that the procoagulant substances activated in this process remain at the site of injury. This control of blood coagulation is accomplished as the procoagulant reactions only exist on specific cell surfaces to keep coagulation from spreading throughout the vascular system.

A model of coagulation that better explains bleeding and thrombosis in vivo created after considering the critical role of cells. The cellbased model of hemostasis replaces the traditional "cascade" hypothesis, and proposes that coagulation takes place on different cell surfaces in four overlapping steps: initiation, amplification, propagation and termination.

The cell-based model allows a more thorough understanding of how hemostasis works in vivo, and sheds light on the pathophysiological mechanism for certain coagulation disorder.

Macfarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biological amplifier. Waterfall sequence for intrinsic blood clotting. Lotspeich-Steininger CA. Introduction to hemostasis. Clinical hematology. New York: J. Lippincott; Blood: principles and practice of hematology. Hoffman M. A cell-base model of coagulation and the role of factor VIIa. Blood Rev. The role of tissue factor in thrombosis and hemostasis.

Physiol Res. Vine AK. Recent advances in haemostasis and thrombosis. Remodeling the blood coagulation cascade. J Thromb Thrombolysis. Theories of blood coagulation. J Pediatr Oncol Nurs. Monroe DM, Hoffman M. The coagulation cascade in cirrosis. Clin Liver Dis. Nemerson Y. Tissue factor and haemostasis. Erratum in: Blood. The structural biology of expression and function of tissue factor. Thromb Haemost.

Rev Esp Cardiol. Boucher BA, Traub O. Achieving hemostasis in the surgical field. Systemic release of thrombomodulin, but not from the cardioplegic, reperfused heart during open heart surgery. Thromb Res. Shearer MJ. Vitamin K. Soluble thrombomodulin antigen in plasma is increased in patients with acute myocardial infarction treated with thrombolytic therapy.

Protein S and C4b-binding protein: components involved in regulation of the protein C anticoagulant system. Resistance to activated protein C and low levels of protein S activity in nine thrombophilic families: a correct diagnosis. Blood Coagul Fibrinolysis. Franco RF. Porto Alegre: Artmed; All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. How to cite this article.

ANASTASIA VLADIMIR MEGRE PDF

Factor de coagulaciĆ³n XI

En humanos, el factor XI se encuentra codificado por el gen F El factor IXa, por otro lado, activa al factor X. Cada cadena posee una masa molecular de aproximadamente 80 El gen de FXI tiene una longitud de 23 kb, posee 15 exones, y se encuentra en el brazo largo del cromosoma 4 4q Niveles elevados de factor XI han sido implicados en casos de trombosis , aunque es incierto que es lo que determina estos niveles, y cuan severo puede ser el estado procoagulante. De Wikipedia, la enciclopedia libre.

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